The derailment happened around 8am Friday after the train slammed into a dump truck. Three cars were thrown from the tracks.
The dump truck driver survived the accident and was taken to Jackson Hospital for treatment. WSFA 12 News has learned the driver, who was not identified, suffered only minor injuries.
The train was pulling approximately 42 cars when the collision took place.
Several of those cars were hauling hazardous materials, officials say, though it is believed none of the materials leaked out. It wasn't immediately known what those hazardous materials were.
Clean up continues and the Montgomery Police Department doesn't expect the roadway to reopen until 5pm at the earliest.
Around 3pm a second train pulled away from the wreckage with the first train's remaining cars.
Authorities say they won't reopen the roadway until an examination of the pavement determines it's safe for travel.