Cancer drug may be helpful for diabetes - WSFA.com: News Weather and Sports for Montgomery, AL.

Cancer drug may be helpful for diabetes

Updated:
© iStockphoto.com / Dr. Heinz Linke © iStockphoto.com / Dr. Heinz Linke
  • HealthMore>>

  • Spouse's sunny outlook may be good for your health

    Spouse's sunny outlook may be good for your health

    Marriage vows often include the promise to stick together for better or for worse, and research now suggests that when it comes to your health, having an optimistic spouse is better.More >>
    Marriage vows often include the promise to stick together for better or for worse, and research now suggests that when it comes to your health, having an optimistic spouse is better.More >>
  • Mental illness not a driving force behind crime

    Mental illness not a driving force behind crime

    TUESDAY, April 22, 2014 (HealthDay News) -- Less than 10 percent of crimes committed by mentally ill people are directly linked to the symptoms of their disorders, a new study shows. "When we hear about crimes committed by people with mental illness, they tend to be big headline-making crimes, so they get stuck in people's heads," said study author Jillian Peterson, a psychology professor at Normandale Community College in Bloomington, Minn. "The vast majority of people with mental illness a...More >>
    TUESDAY, April 22, 2014 (HealthDay News) -- Less than 10 percent of crimes committed by mentally ill people are directly linked to the symptoms of their disorders, a new study shows. "When we hear about crimes committed by people with mental illness, they tend to be big headline-making crimes, so they get stuck in people's heads," said study author Jillian Peterson, a psychology professor at Normandale Community College in Bloomington, Minn. "The vast majority of people with mental illness a...More >>
  • A little wine might help kidneys stay healthy

    A little wine might help kidneys stay healthy

    An occasional glass of wine might help keep your kidneys healthy, new research suggests.More >>
    An occasional glass of wine might help keep your kidneys healthy, new research suggests.More >>

SUNDAY, Sept. 15 (HealthDay News) -- The cancer drug Zaltrap (aflibercept) could help treat diabetes, suggest findings from research using mice.

Scientists say they've identified a molecular pathway (a series of interactions among proteins) involved in the development of diabetes, and also found that the drug can regulate this pathway.

Zaltrap is approved in the United States to treat metastatic (spreading) colorectal cancer and the wet form of the eye disease macular degeneration. The drug inhibits the vascular endothelial growth factor (VEGF) pathway, thereby blocking the growth of blood vessels into tumors and starving them of oxygen.

The researchers, from the Stanford University School of Medicine, identified a series of proteins that link VEGF inhibitors and blood glucose levels.

"We were surprised to find that this drug currently used in patients for cancer treatment had beneficial effects on diabetes in laboratory mice and could, potentially, in humans," Dr. Calvin Kuo, a professor of medicine, said in a university news release.

Scientists caution, however, that research with animals often fails to provide similar results in humans.

"Proteins involved in this pathway could be targeted for the development of new diabetes therapies," Amato Giaccia, a professor of cancer biology and director of radiation oncology, said in the news release.

The findings appeared online Sept. 15 in two articles in the journal Nature Medicine.

The researchers said there have been indications that VEGF inhibitors such as Zaltrap could influence blood glucose levels in people, but no human studies have been conducted.

"Anecdotally, there have been reports that diabetic patients who have been prescribed VEGF inhibitors to treat their cancer are better able to control their diabetes," Kuo said.

Three co-authors of Kuo's study are employees at Regeneron Pharmaceuticals, which makes aflibercept.

More information

The U.S. National Institute of Diabetes and Digestive and Kidney Diseases has more about diabetes.

Copyright © 2013 HealthDay. All rights reserved.

*DISCLAIMER*: The information contained in or provided through this site section is intended for general consumer understanding and education only and is not intended to be and is not a substitute for professional advice. Use of this site section and any information contained on or provided through this site section is at your own risk and any information contained on or provided through this site section is provided on an "as is" basis without any representations or warranties.
Powered by WorldNow