UAB study identifies new way brain tumors become more malignant - WSFA.com: News Weather and Sports for Montgomery, AL.

UAB study identifies new way brain tumors become more malignant

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(Source: WBRC) (Source: WBRC)
BIRMINGHAM, AL (WSFA) -

A strategy that aggressive brain tumor cells use to fuel their expansion has been identified by researchers at the University of Alabama at Birmingham.

Markus Bredel, M.D., Ph.D., professor in the UAB Department of Radiation Oncology and senior scientist in the neuro-oncology program at the UAB Comprehensive Cancer Center, and colleagues show how a phenomenon known as 'alternative splicing' allows brain tumors to incapacitate a key tumor suppressor gene, and that splicing happens in a tissue-specific context in a study published online in The Journal of Clinical Investigation.

Glioblastoma multiforme, the deadliest and most common form of malignant brain tumor, is "probably one of the most aggressive human cancers," Bredel says

Brain tumors are a serious medical problem that have few options for a cure or long-term effective treatment.

For more information visit http://www.uab.edu/news/innovation/item/4739-uab-study-identifies-new-way-brain-tumors-become-more-malignant.

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