Arnold Hughey threw 6 2/3 strong innings and Karl Amonite hit his sixth home run of the season but a two-run sixth inning carried Mississippi State past the Tigers, 4-1, in the series opener on Friday night in Starkville.
With the loss the Tigers fall to 21-12, 5-5 SEC while the Bulldogs up their record to 19-7, 5-4 SEC.
Amonite knotted the score at 1-1 in the top of the fourth as the first baseman hammered MSU starting pitcher Alan Johnson's offering over the fence in right-center for his sixth home run of the season.
Mississippi State had their leadoff hitter reach safely in five innings with three of those runners reaching home.
Hughey allowed four runs (three earned) on seven hits with two strikeouts but suffered his third loss of the season to fall to 3-3. It marked the third time this season that he has allowed three or fewer earned runs and was saddled with the loss.
Catcher Josh Bell extended his career-high hitting streak to 12 games with his single in the seventh. He finished the game 2-for-4.
Reliever John Madden pitched a solid inning and 2/3, allowing just one hit.
Johnson earned the win for the Bulldogs, allowing just one run on six hits with six strikeouts in eight full innings of work.
Brett Cleveland picked up his first save of the year for the Bulldogs.